Intermolecular Three-Component Synthesis of Fluorene Derivatives by a Rhodium-Catalyzed Stitching Reaction/Remote Nucleophilic Substitution Sequence

DOI: 10.1021/acs.joc.0c00790

Source and publish data:

Journal of Organic Chemistry p. 8489 - 8500 (2020)

Update date:2022-08-05

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Authors:

Nishida, Masaki

Lee, Donghyeon

Shintani, Ryo

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Article abstract of DOI:10.1021/acs.joc.0c00790

A three-component synthesis of multisubstituted fluorene derivatives has been developed by devising a rhodium-catalyzed stitching reaction/remote nucleophilic substitution sequence. A variety of nucleophiles can be installed in the second step including both heteroatom and carbon nucleophiles. An efficient synthesis of 5H-benzo[a]fluoren-5-ones has also been realized using N-(2-alkynyl)benzoylpyrrole as the reaction partner through a new reaction pathway.

Full text of DOI:10.1021/acs.joc.0c00790

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