Tetrahedron Letters p. 2101 - 2102 (2001)
Update date:2022-08-05
Topics:
Zhao, Rulin
Gove, Stacey
Sundeen, Joseph E.
Chen, Bang-Chi
A new facile method has been developed for the synthesis of 2-aminothiazole-5-carboxylates. The new method involves reaction of ethyl β-ethoxyacrylate with N-bromosuccinimide (NBS) to give a novel intermediate, α-bromo-α-formylacetate hemiacetal. Cyclization of the in situ formed hemiacetal with thioureas afforded 2-aminothiazole-5-carboxylates in 60-98% yields.
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