Journal of Medicinal Chemistry p. 1358 - 1363 (1980)
Update date:2022-08-03
Topics:
Koga, Hiroshi
Itoh, Akira
Murayama, Satoshi
Suzue, Seigo
Irikura, Tsutomu
Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.
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Doi:10.1002/1521-3773(20010401)40:7<1216::AID-ANIE1216>3.0.CO;2-W
(2001)Doi:10.3987/COM-01-9168
(2001)Doi:10.1039/b009599k
(2001)Doi:10.1016/j.ica.2007.02.037
(2008)Doi:10.1016/S0022-328X(00)82919-8
(1972)Doi:10.1039/C29710001454
(1971)