REACTION OF AROMATIC AND HETEROAROMATIC COMPOUNDS BEARING ELECTRON-ACCEPTING SUBSTITUENTS. 25. SYNTHESIS OF (5-BENZYL-3-THIENYL)METHANOL FROM 2-BENZOYLTHIOPHENE

Article abstract of DOI:10.1007/BF00552773

Under the action of paraformaldehyde and AlCl3, 2-benzoylthiophene has been converted into 2-benzoyl-4-chloromethylthiophene, which on treatment with anhydrous sodium acetate has given 4-acetoxymethyl-2-benzoylthiophene.The reduction and simultaneous saponification of the latter under the conditions of the Kizhner reaction has yielded (5-benzyl-3-thienyl)methanol.