Water-soluble class C β-lactamase catalytic residue mimic: Effect of proximally positioned functional groups on their pKa values

Article abstract of DOI:10.1016/S0040-4039(97)10486-5

Molecules mimicing class C β-lactamase catalytic residues were synthesized to study the effect of proximal positioning of serine, lysine and tyrosine side chains on their pKa values. The three amino acid side chains were mimicked by hydroxymethyl group, a