Journal of Medicinal Chemistry p. 6447 - 6450 (2004)
Update date:2022-07-30
Topics:
Stachel, Shawn J.
Coburn, Craig A.
Steele, Thomas G.
Jones, Kristen G.
Loutzenhiser, Elizabeth F.
Gregro, Alison R.
Rajapakse, Hemaka A.
Lai, Ming-Tain
Crouthamel, Ming-Chih
Xu, Min
Tugusheva, Katherine
Lineberger, Janet E.
Pietrak, Beth L.
Espeseth, Amy S.
Shi, Xiao-Ping
Chen-Dodson, Elizabeth
Holloway, M. Katharine
Munshi, Sanjeev
Simon, Adam J.
Kuo, Lawrence
Vacca, Joseph P.
We describe the development of cell-permeable β-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an artificial amyloid precursor protein in cell culture. In addition to potent inhibition in a cell
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