Bioorganic and Medicinal Chemistry Letters p. 1799 - 1802 (2005)
Update date:2022-08-05
Topics:
Li, James J.
Wang, Haixia
Qu, Fucheng
Musial, Christa
Tino, Joseph A.
Robl, Jeffrey A.
Slusarchyk, Dorothy
Golla, Rajasree
Seethala, Ramakrishna
Dickinson, Kenneth
Giupponi, Leah
Grover, Gary
Sleph, Paul
Flynn, Neil
Murphy, Brian J.
Gordon, David
Kung, Melissa
Stoffel, Robert
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
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