3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester
• CAS No.: 350014-20-9
• Molecular Formula: C₂₃H₂₇NO₅
• Molecular Weight: 397.471
• Mol file: 350014-20-9.mol

Synonyms:3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester

Chemical Property of 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester

There total 8 articles about 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl bromide (100-39-0) + methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate (350014-19-6) → 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester (350014-20-9)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide);

Reference yield: 77.0%

→ 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester (350014-20-9)

Guidance literature:

Reference yield:

m-tyramine (588-05-6) → 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester (350014-20-9)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. HCl

2: TMSiCl

3: Et₃N

4: NaH

With hydrogenchloride; chloro-trimethyl-silane; sodium hydride; triethylamine;

DOI:10.1016/j.bmcl.2005.02.040

upstream raw materials:

benzyl bromide

methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate

m-tyramine

rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Downstream raw materials:

6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester

6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

C₂₂H₂₄NO₅^(1-)*Na⁽¹⁺⁾