REGIOSELECTIVE SYNTHESIS OF 4-ALKYLPYRIDINES VIA 1,4-DIHYDROPYRIDINE DERIVATIVES FROM PYRIDINE

DOI: 10.1016/S0040-4039(00)86851-3

Source and publish data:

Tetrahedron Letters p. 429 - 432 (1982)

Update date:2022-08-04

Topics:

Authors:

Akiba, Kin-ya

Iseki, Yuji

Wada, Makoto

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Article abstract of DOI:10.1016/S0040-4039(00)86851-3

N-Ethoxycarbonylpyridinium chloride (1) reacted with at 4-position with almost complete regioselectivity (better than 99percent) to afford the corresponding 1,4-dihydropyridine derivatives (2) in high yields (81 ca. 94percent).The dihydropyridines were readily oxidized by oxygen to give 4-alkylpyridines (4:38 ca. 68percent yields).

Full text of DOI:10.1016/S0040-4039(00)86851-3

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