Helvetica Chimica Acta p. 887 - 897 (1986)
Update date:2022-07-30
Topics:
Maag, Hans
Locher, Rita
Daly, John J.
Kompis, Ivan
Based on a computer-assisted analysis of the three-dimensional structure of the binary complex of E.coli dihydrofolate reductase (DHFR) with methotrexate, 5-(N-arylnortropan-3-yl)- and 5-(N-arylpiperidin-4-yl)-2,4-diaminopyrimidines 2 and 4 were designed
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