A four-step route from aldehydes to C2-elongated enantiomerically pure α,β-unsaturated γ-hydroxy esters

Article abstract of DOI:10.1055/s-2001-13372

Asymmetric dihydroxylation of β,γ-unsaturated esters 4 provided β-hydroxy-γ-lactones 3 or ent-3. Methanolysis acetonide formation and LDA-mediated fragmentation of the resulting esters 5/ent-5 furnished the γ-chiral acrylates 6/ent-6 containing disubstitu