Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands

DOI: 10.1016/S0960-894X(99)00194-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1409 - 1414 (1999)

Update date:2022-09-26

Topics:

Authors:

Cordi Cordi

Lacoste Lacoste

Audinot Audinot

Millan Millan

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Article abstract of DOI:10.1016/S0960-894X(99)00194-8

The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a) was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site.

Full text of DOI:10.1016/S0960-894X(99)00194-8

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