Bioorganic and Medicinal Chemistry Letters p. 1409 - 1414 (1999)
Update date:2022-09-26
Topics:
Cordi
Lacoste
Audinot
Millan
The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a) was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site.
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