Chemical and Pharmaceutical Bulletin p. 1214 - 1220 (1999)
Update date:2022-09-26
Topics:
Bala Show Reddy
Venkata Rao
Bheemasankara Rao
Dhananjaya
Kuttan
Babu
Two new sphingolipids, (2S,3S,4R)-1,3,4-trihydroxy-2-[((R)-2'- hydroxytetradecanoyl) amino] tricosane (4) and (2S,3S,4R)-1,3,4-triacetoxy-2- [((R)-2'-acetoxyoctadecanoyl) aminoloctadecane (5) along with africanene (1, reasonably good yield), 23-demethylgargosterol (2) and batylalcohol (3) have been isolated from the soft coral Sinularia leptoclados. Preliminary studies for pharmacological activity (blind screening and toxicity studies) of africanene were conducted. Africanene exhibited in vitro and in vivo cytotoxicity, dose dependent hypotensive activity as well as antiinflammatory activity. The pharmacological and toxicity studies on africanene are being reported for the first time and findings strongly encourage further investigation. Compounds 1, 4 and 5 were studied for the antibacterial, antifungal and antiviral activity while compounds 4 and 5 were also studied for the short term in vitro cytotoxic activity.
View MoreContact:+86-021-58123769
Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd
Contact:+86-791-86899381
Address:Nanchang, Jiangxi, China
Ningbo Tide Imp. & Exp. Co., Ltd.
Contact:+86-571-8993 7933; +86-571-8993 6453
Address:7/F Anno Domini Building, Tower South, 8 Qiu Shi Road,Hangzhou,China.
Anhui Xinyuan Technology Co.,Ltd
Contact:0086-559-3515800
Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China
Hangzhou yi lu biont technology Co., LTD
Contact:+86-571-88152630
Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
Doi:10.1021/om0102551
(2001)Doi:10.1016/S0014-827X(01)01074-6
(2001)Doi:10.1021/jo980604+
(1998)Doi:10.1002/chem.201904147
(2020)Doi:10.1007/BF01153921
(1976)Doi:10.1002/chem.201501884
(2015)
