18-Substituted Steroids. Part 8. An Improved Synthesis of 11β,18,21-Trihydroxypregn-4-ene-3,20-dione ('18-Hydroxycorticosterone')

DOI: 10.1039/P19810000703

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 703 - 705 (1981)

Update date:2022-08-04

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Authors:

Kirk, David N.

Slade, Christopher J.

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Article abstract of DOI:10.1039/P19810000703

'18-Hydroxycorticosterone' (1) has been prepared from 11β-formyloxy-20-hydroxypregn-4-en-3-one (6) by application of the 'hypoiodite' series of reactions , followed by acetoxylation at C-21 by lead tetra-acetate in acetic acid.Alkaline hydrolysis then gave 18-hydroxycorticosterone.

Full text of DOI:10.1039/P19810000703

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