Ring expansion: Formal total synthesis of (-)-paroxetine

Article abstract of DOI:10.1016/S0040-4039(01)01096-6

A ring expansion and a radical dehalogenation have been used as the key steps in a formal total synthesis of (-)-paroxetine. A stereoselective ring expansion of prolinol generated the substituted piperidine ring precursor of (-)-paroxetine.