Tetrahedron Letters p. 4195 - 4198 (1982)
Update date:2022-08-03
Topics:
Fraser, Robert R.
Baignee, Alison
Bresse, Monique
Hata, Kazumi
The changes in 13C chemical shifts for the structural change R2NH -> R2N-Li have been measured for a series of dialkylamines.These lithiation shifts are largest at the alpha carbon (3.7-9.7 ppm) and decrease in the order α > β > χ > δ.The rates of lithium-hydrogen interchange between R2NH and R'2N-Li have been determined.The activation energies are large (9 - 17 kcal/mole) and increase as the size of R or R' increases.The slow exchange permits the direct measurement of acidity differences between pairs of amines using 13C nmr.
View MoreEngineering Research Center of Pesticide, Heilongjiang Province
Contact:+86-451-86609001
Address:No.74 of Xuefu Road, Nangang District,
Contact:+86-371-55981030
Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan
Nanjing Vincero International Trading Co.,Ltd
Contact:8618936897229
Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Daqing E-shine Chemical Co.,LTD
Contact:0086-024-31285112
Address:Hongweiyuan area, Ranghulu district
Jewim Pharmaceutical (Shandong) Co., Ltd
Contact:+8615621883869
Address:山东省泰安市高新技术产业开发区配天门大街西首
Doi:10.1021/jo00408a019
(1978)Doi:10.1021/jo010687l
(2001)Doi:10.1021/acs.joc.6b02451
(2016)Doi:10.1016/S0040-4039(01)01664-1
(2001)Doi:10.1016/S0008-6215(01)00194-X
(2001)Doi:10.1021/ja01604a022
(1956)