F
W. Xu et al.
Letter
Synlett
R1
R3
R1
NH
R2
Cu2O/ligand
N
R2
O
H2O
R3
H
O
N
O
N
O
O
oxidation
NAr
R3
addition
NHAr
R3
NHAr
NAr
R3
condensation
NH2
N
H
B
A
C
Scheme 3 Proposed mechanism
desired products in moderate to good yields. Further stud-
ies focusing on expanding the scope of the reaction are cur-
rently underway in our laboratory.
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Acknowledgment
We thank the National Natural Science Foundation of China (Nos.
21102104, 21272177), the Natural Science Foundation of Zhejiang
Province (Nos. LY14B020011, LY15B020002), the Foundation of Zheji-
ang Province Department of Education (No. Y201327597), and Wen-
zhou University for their financial support.
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Supporting Information
Supporting information for this article is available online at
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© Georg Thieme Verlag Stuttgart · New York — Synlett 2016, 48, A–G