The first asymmetric synthesis of polyfunctionalized 4H-pyrans via Michael addition of malononitrile to 2-acyl acrylates

Article abstract of DOI:10.1016/0040-4039(92)80031-E

Starting from (R)-2,3-O-isopropylideneglyceraldehyde, the first asymmetric synthesis of 4H-pyrans (4) has been developed; a detailed X-ray structural and stereochemical study has established as R the absolute configuration at the new stereocenter in compounds 4.