Enantiodivergent synthesis of either enantiomer of ABCDE-ring analogue of antitumor antibiotic fredericamycin A via intramolecular [4 + 2] cycloaddition approach

Article abstract of DOI:10.1021/ol016696y

matrix presented An intramolecular enantiodivergent synthesis of both enantiomers of the ABCDE-ring analogue 22 of fredericamycin A is reported. Key steps involved an intramolecular [4 + 2] cycloaddition of 17 and an aromatic Pummerer-type reaction of 19.