SYNTHESIS OF CHIRAL TRIPEPTIDES BY ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDES. REMARKABLE EFFECTS OF N-PROTECTING GROUPS ON STEREOSELECTIVITY AND REACTIVITY

Article abstract of DOI:10.1016/S0040-4039(00)87741-2

Dehydrotripeptides, X-CH(Rⁱ)-ΔPhe-CH(R^k)COOMe (3: X = ^tBOC-NH, CBZ-NH, CF3CONH and N3), were employed for the asymmetric hydrogenation catalyzed by chiral rhodium complexes and it was found that ^tBOC-3 brought a