A facile one-pot synthesis and antibacterial activity of aziridines and thiazines from 1,3-diarylprop-2-enones

Article abstract of DOI:10.1080/10426500108040582

The title compounds 1a,b as examples for acyclic alkenones were utilized for the synthesis of some heterocycles namely, thiazines 2a,b and 3a-d, pyrimidines 4a,b, aziridines 7a,b. The unexpected tribromides 8a,b, obtained from bromination of 1a,b, were readily used to afford the pyrazoles 9a,b and isoxazoles 10 a,b. Biological screening of some selective synthesised compounds was determined in vitro using Gram-negative and Gram-positive bacterial strains.

Full text of DOI:10.1080/10426500108040582

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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A FACILE ONE-POT SYNTHESIS
AND ANTIBACTERIAL ACTIVITY
OF AZIRIDINES AND THIAZINES
FROM 1,3-DIARYLPROP-2-
ENONES
H. M. F. Madkour a , M. A. I. Salem a , E. A. Soliman a
& N. F. H. Mahmoud a
a Synthetic Organic Chemistry Laboratory, Chemistry
Department, Faculty of Science , Ain Shams
University , Abbasiya, Cairo, Egypt
Published online: 27 Oct 2006.
To cite this article: H. M. F. Madkour , M. A. I. Salem , E. A. Soliman & N. F. H.
Mahmoud (2001) A FACILE ONE-POT SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF
AZIRIDINES AND THIAZINES FROM 1,3-DIARYLPROP-2-ENONES, Phosphorus, Sulfur, and
Silicon and the Related Elements, 170:1, 15-27, DOI: 10.1080/10426500108040582
To link to this article: http://dx.doi.org/10.1080/10426500108040582
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