An aldol-based approach to the synthesis of the antibiotic anisomycin

Article abstract of DOI:10.1021/ol017016u

Chemical equation presented A new approach to the synthesis of the antibiotic anisomycin is reported that relies upon a key aldol disconnection. The glycolate aldol coupling proceeds in 75% yield and with >95% diastereoselectivity, which allows the 13-step synthesis to proceed in 35% overall yield.