Journal of Medicinal Chemistry p. 2918 - 2929 (1994)
Update date:2022-08-05
Topics:
Harbeson, Scott L.
Abelleira, Susan M.
Akiyama, Alan
Barrett, Robert
Carroll, Renee M.
et al.
Peptidyl α-keto amides have been synthesized and tested as inhibitors of the cysteine protease calpain.A stereospecific synthesis was devised in which Cbz-dipeptidyl-α-hydroxy amides were oxidized with TEMPO/hypochlorite to the corresponding α-keto amides
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