New enediyne derivatives: Synthesis of symmetrically and unsymmetrically disubstituted 4,5-dialkynyl-3(2H)-pyridazinones

DOI: 10.1016/S0040-4020(01)01030-4

Source and publish data:

Tetrahedron p. 10009 - 10016 (2001)

Update date:2022-07-31

Topics:

Authors:

R'kyek, Omar

Maes, Bert U.W

Jonckers, Tim H.M

Lemière, Guy L.F

Dommisse, Roger A

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Article abstract of DOI:10.1016/S0040-4020(01)01030-4

4,5-Dialkynyl-2-(methyl or phenyl)-3(2H)-pyridazinones (2a-c) were efficiently prepared via Sonogashira cross-coupling reaction on 4,5-dichloro-2-(methyl or phenyl)-3(2H)-pyridazinones (1a,b). Selective Sonogashira reactions were successfully achieved on

Full text of DOI:10.1016/S0040-4020(01)01030-4

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