REGIO- AND STEREOSELECTIVE HYDROGENATION OF METHYL SUBSTITUTED PENTADIEN-1-OLS BY BAKER'S YEAST

Article abstract of DOI:10.1016/S0040-4020(01)85910-X

(E)-2-methyl and (E)-3-methyl-2,4-pentadien-1-ols are reduced to (S)-2-methyl- and (S)-3-methyl-4-penten-1-ols, respectively, using baker's yeast as a regio- and stereoselective reagent.This microbiological conversion provides an efficient route to bifunctional and enantiomerically pure C6-building blocks containing the C'-CH(Me)-C'' grouping.