Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives

Article abstract of DOI:10.1016/j.farmac.2003.10.003

As a follow up of our previous structure-activity relationship and molecular modeling studies, we synthesized a novel series of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as potential non-competitive AMPA receptor antagonists. When te