Bioorganic and Medicinal Chemistry p. 6356 - 6374 (2011)
Update date:2022-08-04
Topics:
Ruchelman, Alexander L.
Man, Hon-Wah
Chen, Roger
Liu, Wei
Lu, Ling
Cedzik, Dorota
Zhang, Ling
Leisten, Jim
Collette, Alice
Narla, Rama Krishna
Raymon, Heather K.
Muller, George W.
A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and phosphodiesterase 4 (PDE4). By using the 3-ethoxy-4-methoxyphenyl PDE4 pharmacophore as one of the aromatic ri
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Doi:10.1016/j.tetasy.2011.11.014
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(2018)
