19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine

DOI: 10.1111/j.2042-7158.1985.tb04991.x

Source and publish data:

Journal of Pharmacy and Pharmacology p. 869 - 873 (1985)

Update date:2022-08-05

Topics:

Authors:

Everett Everett

Jennings

Woodnutt

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Article abstract of DOI:10.1111/j.2042-7158.1985.tb04991.x

¹⁹F NMR spectroscopy was used to monitor the metabolites of flucloxacillin in the urine of a rat dosed with its sodium salt. ¹⁹F NMR signals were detected and quantified from flucloxacillin and three metabolites. The ¹⁹F NMR method involves minimal sample preparation and is free from interference by endogenous urine components. High-field spin-echo ¹H NMR spectroscopy and HPLC were used to confirm the results.

Full text of DOI:10.1111/j.2042-7158.1985.tb04991.x

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