Design, Synthesis, and Biological Activity of 4-[(4-Cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as Potent and Selective Farnesyltransferase Inhibitors

DOI: 10.1021/jm030434f

Source and publish data:

Journal of Medicinal Chemistry p. 612 - 626 (2004)

Update date:2022-08-04

Topics:

Authors:

Wang, Le

Wang, Gary T.

Wang, Xilu

Tong, Yunsong

Sullivan, Gerry

Park, David

Leonard, Nicholas M.

Li, Qun Li, Qun

Cohen, Jerry

Gu, Wen-Zhen

Zhang, Haiying

Bauch, Joy L.

Jakob, Clarissa G.

Hutchins, Charles W.

Stoll, Vincent S.

Marsh, Kennan

Rosenberg, Saul H.

Sham, Hing L.

Lin, Nan-Horng

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Article abstract of DOI:10.1021/jm030434f

A novel series of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles have been synthesized as selective farnesyltransferase inhibitors using structure-based design. X-ray cocrystal structures of compound 20-FTase-HFP and A313326-

Full text of DOI:10.1021/jm030434f

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Product name:4-[(4-iodo-2-nitrobenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitrile

Cas No:450841-51-7

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