The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor.

DOI: 10.1016/S0968-0896(01)00418-7

Source and publish data:

Bioorganic and medicinal chemistry p. 1509 - 1523 (2002)

Update date:2022-08-03

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Authors:

Hirayama, Fukushi

Koshio, Hiroyuki

Katayama, Naoko

Kurihara, Hiroyuki

Taniuchi, Yuta

Sato, Kazuo

Hisamichi, Nami

Sakai-Moritani, Yumiko

Kawasaki, Tomihisa

Matsumoto, Yuzo

Yanagisawa, Isao

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Article abstract of DOI:10.1016/S0968-0896(01)00418-7

Since Factor Xa (FXa) is well known to play a central role in thrombosis and hemostasis, inhibition of FXa is an attractive target for antithrombotic strategies. As a part of our investigation of a non-peptide, orally available FXa inhibitor, we found tha

Full text of DOI:10.1016/S0968-0896(01)00418-7

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