Total synthesis of an anticancer agent, mucocin. 2. A novel approach to a γ-hydroxy butenolide derivative and completion of total synthesis

Article abstract of DOI:10.1016/S0040-4039(98)02440-X

Total synthesis of mucocin (1) was accomplished through a palladium- catalyzed cross coupling reaction of the C₁₀-C₃₄ fragment of I and a newly designed γ-hydroxy butenolide subunit, which was synthesized by taking advantage of radic