The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating hydantoin or uracil rings

Article abstract of DOI:10.1016/j.bmc.2011.05.064

A series of novel, potent and selective human β₂ adrenoceptor agonists incorporating a hydantoin or a uracil ring on the right-hand side phenyl ring of (R)-salmeterol is presented. Hydantoin 12a had long duration of action in vitro on guinea pi