Bioorganic and Medicinal Chemistry Letters p. 2317 - 2321 (2007)
Update date:2022-07-31
Topics:
Velaparthi, Upender
Wittman, Mark
Liu, Peiying
Stoffan, Karen
Zimmermann, Kurt
Sang, Xiaopeng
Carboni, Joan
Li, Aixin
Attar, Ricardo
Gottardis, Marco
Greer, Ann
Chang, ChiehYing Y.
Jacobsen, Bruce L.
Sack, John S.
Sun, Yax
Langley, David R.
Balasubramanian, Balu
Vyas, Dolatrai
The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the
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