Base-catalyzed hydroamination of aromatic olefins - An efficient route to 1-aryl-4-(arylethyl)piperazines

Article abstract of DOI:10.1016/S0040-4020(98)00295-6

An efficient synthesis of pharmaceutically interesting 1-aryl-4- (arylethyl)-piperazines by base-catalyzed hydroamination is presented. Starting from substituted aryl olefins and various N-arylpiperazines, the desired products 3 - 12 were obtained in one