Tetrahedron p. 4085 - 4089 (2002)
Update date:2022-08-05
Topics: Lipase Regioselectivity Enantiomeric excess (ee) Hydrolysis Esterification Enantiomers Partitioning Stereoselectivity Catalysis Kinetic Resolution Substrate Specificity Enzymatic Resolution Biotransformation Chiral Separation Racemic mixture Fluorous tag Immiscible phases
Swaleh, Sauda M
Hungerhoff, Benno
Sonnenschein, Helmut
Theil, Fritz
Simultaneous enantiomer-selective fluorous-phase delabeling and kinetic resolution was achieved by lipase-catalyzed alcoholysis of highly fluorinated esters of racemic alcohols. The separation of the fast-reacting delabeled enantiomers and the slow-reacting fluorous-phase labeled enantiomers was performed very efficiently by partition in an organic/fluorous biphasic solvent system.
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