Bioorganic and Medicinal Chemistry Letters p. 3713 - 3716 (2005)
Update date:2022-07-31
Topics:
St.-Denis
Di Fabio
Bernasconi
Castiglioni
Contini
Donati
Fazzolari
Gentile
Ghirlanda
Marchionni
Messina
Micheli
Pavone
Pasquarello
Sabbatini
Zampori
Arban
Vitulli
Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented.
View Morewebsite:http://www.win-winchemical.com
Contact:0086-577-64498589
Address:6F, No. 396 Xingping Road, Longwan Industrial Zone, Wenzhou City, Zhejiang, 325000 P.R.China
Contact:13813902930 025-52714267
Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
Contact:18698110882
Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
Contact:86-21-50966856
Address:Building 5,300 Chuanzhan Road,Pudong New District,Shanghai
Zibo Ocean International Trade Co.,Ltd(expird)
Contact:+86 533 5160706
Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China
Doi:10.1016/S0960-894X(00)00262-6
(2000)Doi:10.1021/jm020848t
(2002)Doi:10.1016/S0960-894X(02)00282-2
(2002)Doi:10.1016/S0040-4020(02)00635-X
(2002)Doi:10.1021/bi301411d
(2012)Doi:10.1021/jo026260b
(2003)