Angewandte
Chemie
D.Vodak, J.Wachter, M.O©Keeffe, O.M.Yaghi,
295, 469.
[4] P.S.Halasyamani, M.J.Drewitt, D.O©Hare,
Science 2002,
MW ¼ 1409.64. Of the 1854 reflections measured (2 < 2q < 56),
1189 symmetry-independent reflections were used to solve the
structure.Based on these data and 114 refined parameters, R1 ¼
0.0642 (all data), wR2 ¼ 0.0870, and GOF (F2) ¼ 1.011. Crystal
data for [C24H46Cu3Eu2N6O32]n (3): 0.33 î 0.18 î 0.17 mm, trigo-
Chem. Commun.
1997, 867; P.J.Hagraman, J.Zubieta, Angew. Chem. 1999, 111,
2798; Angew. Chem. Int. Ed. 1999, 38, 2634; S.A.Bourne, J.J.
Lu, A.Mondal, B.Moulton, M.J.Zaworotko,
2001, 113, 2171; Angew. Chem. Int. Ed. 2001, 40, 2111; J.J.Lu, A.
Mondal, B.Moulton, M.J.Zaworotko, Angew. Chem. 2001, 113,
2174; Angew. Chem. Int. Ed. 2001, 40, 2113.
ꢀ
nal, space group P3c1 (no.165), a ¼ 13.306(5), c ¼ 14.528(5) ä,
Angew. Chem.
g ¼ 1208,
V¼ 2227.6(14) ä3,
Z ¼ 2,
1calcd ¼ 2.101 gcmÀ3
,
m(MoKa) ¼ 4.291 mmÀ1, MW ¼ 1425.08. Of the 1533 reflections
measured (2 < 2q < 56), 1468 symmetry-independent reflections
were used to solve the structure.Based on these data and
107 refined parameters, R1 ¼ 0.0497 (all data), wR2 ¼ 0.1143,
GOF (F2) ¼ 1.127. Crystal data for [C24H38Cu3La2N6O29]n (1a):
[5] J.Kim, B.L.Chen, T.M.Reineke, H.L.Li, M.Eddaoudi, D.B.
Moler, M.O©Keeffe, O.M.Yaghi, J. Am. Chem. Soc. 2001, 123,
8239; M. Eddaoudi, D.B. Moler, H.L. Li, B.L. Chen, T.M.
Reineke, M.O©Keeffe, O.M.Yaghi, Acc. Chem. Res. 2001, 34,
133.
[6] R.Kitaura, K.Fujimoto, S-.I.Noro, M.Kondo, S.Kitagawa,
Angew. Chem. 2002, 114, 141; Angew. Chem. Int. Ed. 2002, 41,
113; A.Escuer, R.Vicente, FA. .Mautner, MA. S. .Goher,
M.A.M.Abu-Youssef, Chem. Commun. 2002, 64; D.T.Vodak,
M.E. Braun, J. Kim, M. Eddaoudi, O.M. Yaghi,
Commun. 2001, 2534.
[7] a) Y.-B. Dong, M. D. Smith, H.-C. zur Loye, Angew. Chem. 2000,
112, 4438; Angew. Chem. Int. Ed. 2000, 39, 4271; b) R.J.
Doedens, E.Yohannes, M.I.Khan, Chem. Commun. 2002, 62;
ꢀ
0.32 î 0.24 î 0.22 mm, trigonal, space group P3c1 (no.165), a ¼
13.5588(3), c ¼ 14.9986(6) ä, g ¼ 1208, V¼ 2387.94(12) ä3, Z ¼
2, 1calcd ¼ 1.857 gcmÀ3, m(MoKa) ¼ 3.157 mmÀ1, MW ¼ 1344.98. Of
the 9010 reflections measured (2 < 2q < 56), 1721 symmetry-
independent reflections were used to solve the structure.Based
on these data and 100 refined parameters, R1 ¼ 0.1017 (all data),
wR2 ¼ 0.2352, GOF (F2) ¼ 1.155. Crystal data for [C24H38Cu3Eu2-
Chem.
ꢀ
N6O29]n (3a): 0.30 î 0.22 î 0.20 mm, trigonal, space group P3c1
(no.165), a ¼ 13.3031(2), c ¼ 14.5660(3) ä, g ¼ 1208, V¼
2232.42(7) ä3,
Z ¼ 2,
1calcd ¼ 2.025 gcmÀ3
,
m(MoKa) ¼
4.273 mmÀ1, MW ¼ 1369.08. Of the 9618 reflections measured
(2 < 2q < 48), 1170 symmetry-independent reflections were used
to solve the structure.Based on these data and 107 refined
parameters, R1 ¼ 0.0359 (all data), wR2 ¼ 0.0881, GOF (F2) ¼
1.091. CCDC-193487 193491 contains the supplementary crys-
tallographic data for this paper.These data can be obtained free
the Cambridge Crystallographic Data Centre, 12, Union Road,
Cambridge CB21EZ, UK; fax: (þ 44)1223-336-033; or deposit
@ccdc.cam.ac.uk).
c) D.M.Ciurtin, M.D.Smith, H.-C.zur Loye,
2002, 74.
Chem. Commun.
[8] Z.Shi, S-.H.Feng, S.Gao, L, -R.Zhang, G.Y.Yang, J.Hua,
Angew. Chem. 2000, 112, 2415; Angew. Chem. Int. Ed. 2000, 39,
2325.
[9] Y.-C. Liang, R. Cao, W.-P. Su, M.-C. Hong, W.-J. Zhang, Angew.
Chem. 2000, 112, 3442; Angew. Chem. Int. Ed. 2000, 39, 3304;
Y.-C. Liang, M.-C. Hong, W.-P. Su, R. -Cao, W.-J. Zhang, Inorg.
Chem. 2001, 40, 4574.
[14] Q.-D. Liu, S. Gao, J.-R. Li, Q.-Z. Zhou, K.-B. Yu, B.-Q. Ma, S.-W.
Zhang, X.-X. Zhang, T.-Z. Jin, Inorg. Chem. 2000, 39, 2488.
[10] DM. J..Doble, CH. .Benison, AJ..Blake, D.Fenske, MS. .
Jackson, R.D.Kay, W-.S.Li, M.Schrˆder,
Angew. Chem. 1999,
111, 2042; Angew. Chem. Int. Ed. 1999, 38, 1915; Y.Pei, P.
Bergerat, O.Kahn, J. Am. Chem. Soc. 1994, 116, 3866; E.
Coronado, J.-R. Galµn-MascarÛs, C.-J. GÛmez-GarcÌa, J. Ens-
ling, P.G¸tlich, Chem. Eur. J. 2000, 6, 552; E.Coronada, C-.J.
GÛmez-GarcÌa, Chem. Rev. 1998, 98, 273; R.Sieber, S.Decur-
tins, H.Stoeckli-Evans, C.Wilson, D.Yufit, J.A.K.Howard,
S.C.Capelli, A.Hauser, Chem. Eur. J. 2000, 6, 361; G.Ballester,
E.Coronado, C.Gimÿnez-Saiz, F.Romero, Angew. Chem. 2001,
113, 814; Angew. Chem. Int. Ed. 2001, 40, 792; E.Coronado, J.R.
Protein-Protein Interactions
œ
Galan-MascarÛs, C.J. GÛmez-GarcÌa, J.M. MartÌnez-Agudo,
Design and Application of an a-Helix-Mimetic
Scaffold Based on an Oligoamide-Foldamer
Strategy: Antagonism of the Bak BH3/Bcl-xL
Complex**
Inorg. Chem. 2001, 40, 113; F.Bellourard, M.Clemente-LeÛn, E.
Coronado, J.R. Gala n-MascarÛs, C.J.GÛmez-GarcÌa, F.Ro-
mero, K.R.Dunbar, Eur. J. Inorg. Chem. 2002, 1603.
œ
[11] B.-Q.Ma, S.Gao, G.Su, G.-X.Xu,
Angew. Chem. 2001, 113, 448;
Angew. Chem. Int. Ed. 2001, 40, 434.
[12] J.M. Dominguez, F. Camara, J.M. Moreno, E. Colacio, H.
Sroeckli, Inorg. Chem. 1998, 37, 3046.
[13] X-ray crystal structure analysis: The data were collected at
Justin T. Ernst, Jorge Becerril, Hyung Soon Park,
Hang Yin, and Andrew D. Hamilton*
293(2) K on
a
CAD4 diffractometer (MoKa radiation; l ¼
0.71073 ä). The structure was solved by direct methods
(SHELXTL Version 5.10) and refined by full-matrix least-
squares on F2.All non-hydrogen atoms were refined anisotropi-
cally.Crystal data for [C 24H46Cu3La2N6O32]n (1): 0.50 î 0.40 î
The design of low-molecular-weight ligands (< 750 Da) that
recognize protein surfaces and subsequently disrupt protein
protein interactions is an area of intense research.[1] Current
strategies for identifying small-molecule protein-surface an-
tagonists primarily involve the use of combinatorial methods.
ꢀ
0.40 mm, trigonal, space group P3c1 (no.165), a ¼ 13.4713(19),
c ¼ 14.922(3) ä, g ¼ 1208, V¼ 2345.3(7) ä3, Z ¼ 2, 1calcd
¼
1.958 gcmÀ3
,
m(MoKa) ¼ 3.223 mmÀ1
,
MW ¼ 1398.98. Of the
2615 reflections measured (2 < 2q < 56), 1708 symmetry-inde-
pendent reflections were used to solve the structure.Based on
these data and 108 refined parameters, R1 ¼ 0.0410 (all data),
wR2 ¼ 0.0757, GOF (F2) ¼ 1.111. Crystal data for [C24H46Cu3Nd2-
[*] Prof. A. D. Hamilton, J. T. Ernst, J. Becerril, Dr. H. S. Park, H. Yin
Department of Chemistry, Yale University
P.O. Box 208107, New Haven, CT 06520-8107 (USA)
Fax: (þ1)203-432-6144
ꢀ
N6O32]n (2): 0.52 î 0.40 î 0.40 mm, trigonal, space group P3c1
E-mail: andrew.hamilton@yale.edu
(no.165), a ¼ 13.4027(19), c ¼ 14.669(3) ä, g ¼ 1208, V¼
2282.0(6) ä3, Z ¼ 2, 1calcd ¼ 2.019 gcmÀ3, m(MoKa) ¼ 3.699 mmÀ1
,
[**] We thank the National Institutes of Health for support of this work.
Angew. Chem. Int. Ed. 2003, 42, No. 5
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