Il Farmaco p. 303 - 313 (2002)
Update date:2022-07-30
Topics:
Di Stefano, Antonio
Sozio, Piera
Luisi, Grazia
Cacciatore, Ivana
Mosciatti, Barbara
Costa, Barbara
Lucacchini, Antonio
Martini, Claudia
Pinnen, Francesco
A series of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes were synthesized and evaluated for their binding affinity toward D1-like and D2-like dopamine (DA) receptors. The affinity and selectivity of these compounds were measured in a test involving displacement of [3H]SCH 23390 or [3H]YM-09-151-2, respectively, from homogenates of porcine striatal membranes. All tested compounds were poorly effective at DA receptors (Ki nM>1000). The results suggest that introduction of chlorine substituent in five or six position of previously synthesized trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes decreases both D1-like and D2-like receptor affinity. Copyright
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Doi:10.1016/j.ejmech.2010.03.011
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(2003)