Synthesis of ODNs containing 4-methylamino-1,8-naphthalimide as a fluorescence probe in DNA

DOI: 10.1016/S0960-894X(02)00404-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2363 - 2366 (2002)

Update date:2022-08-05

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Authors:

Kawai, Kiyohiko

Kawabata, Kazuhiro

Tojo, Sachiko

Majima, Tetsuro

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Article abstract of DOI:10.1016/S0960-894X(02)00404-3

Synthesis and fluorescence properties of oligodeoxynucleotides containing 4-methylamino-1,8-naphthalimide (NI) have been described. NI was successfully incorporated into DNA without significant destabilization of DNA whilst retaining its high fluorescence quantum yield. The attachment site of the NI greatly affected its property as an energy acceptor in FRET analysis.

Full text of DOI:10.1016/S0960-894X(02)00404-3

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