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B. Roy, B. Mukhopadhyay / Tetrahedron Letters 48 (2007) 3783–3787
6. (a) Kappe, C. O. Angew. Chem., Int. Ed. 2004, 43, 6250–
170.7, 170.2 (3 · COCH3), 169.3 (NHCOCH3), 96.6 (C-1),
78.6 (CH2AC„CH), 75.9 (CH2AC„CH), 71.3, 68.7,
68.4, 62.1 (CH2AC„CH), 55.6 (C-6), 53.7 (C-2), 23.3
(NHCOCH3), 21.0, 20.9, 20.8 (3 · COCH3). HRMS:
Calcd for C17H27O9N2 (M+NH4): 403.1717; found m/z
6284; (b) Heard, D. D.; Barker, R. J. Org. Chem. 1968, 33,
740–746; (c) Ferrier, R. J.; Hatton, L. R. Carbohydr. Res.
1968, 6, 75–86; (d) Freudenberg, K. Adv. Carbohydr.
Chem. 1966, 21, 2–38.
1
7. Bornaghi, L. F.; Poulsen, S.-A. Tetrahedron Lett. 2005, 46,
3485–3488.
403.1720. Compound 5: H NMR (CDCl3, 300 MHz) d:
5.23 (dd, 1H, J 2.4 Hz, 9.6 Hz, H-3), 5.21 (br s, 1H, H-2),
5.02 (t, 1H, J 9.6 Hz, H-4), 4.90 (s, 1H, H-1), 4.24 (d, 2H, J
2.4 Hz, CH2AC„CH), 3.87 (m, 1H, H-5), 2.45 (t, 1H, J
2.4 Hz, CH2AC„CH), 2.16, 2.03, 1.98 (3s, 9H,
3 · COCH3), 1.24 (d, 3H, J 7.2 Hz, H-6). 13C NMR
(CDCl3, 50 MHz) d: 169.8, 169.7 (2) (3 · COCH3), 96.4
(C-1), 78.6 (CH2AC„CH), 75.7 (CH2AC„CH), 71.2,
69.9, 69.3, 67.2, 54.9 (CH2AC„CH), 21.1, 21.0, 20.9
(3 · COCH3), 17.6 (C-CH3). HRMS: Calcd for
C15H24O8N (M+NH4): 346.1502; found m/z 346.1503.
Compound 6: 1H NMR (CDCl3, 300 MHz) d: 5.24 (dd,
1H, J 3.3 Hz, 8.7 Hz, H-3), 5.22 (br d, 1H, J 3.3 Hz, H-4),
5.18 (d, 1H, J 3.6 Hz, H-1), 5.05 (dd, 1H, J 3.6 Hz, 8.7 Hz,
H-2), 4.20 (d, 2H, J 2.4 Hz, CH2AC„CH), 4.16 (q, 1H, J
6.6 Hz, H-5), 2.40 (t, 1H, J 2.4 Hz, CH2AC„CH), 2.13,
2.04, 1.94 (3s, 9H, 3 · COCH3), 1.11 (d, 3H, J 6.6 Hz, H-
6). 13C NMR (CDCl3, 50 MHz) d: 170.0, 169.8, 169.5
(3 · COCH3), 94.9 (C-1), 78.6 (CH2AC„CH), 75.1
(CH2AC„CH), 71.2, 67.7 (2), 64.9, 55.4 (CH2AC„CH),
20.6, 20.5, 20.4 (3 · COCH3), 16.0 (C-CH3). HRMS:
Calcd for C15H24O8N (M+NH4): 346.1502; found
m/z 346.1505. Compound 8: 1H NMR (CDCl3,
300 MHz) d: 5.78 (m, 1H, CH2ACH@CH2), 5.43 (t, 1H,
J 10.2 Hz, H-3), 5.35–5.21 (2d, 2H, CH2ACH@CH2),
5.08 (d, 1H, J 3.9 Hz, H-1), 5.04 (t, 1H, J 6.3 Hz, J
10.2 Hz, H-4), 4.86 (dd, 1H, J 3.9 Hz, 10.2 Hz, H-2), 4.18–
4.11 (m, 2H, CH2ACH@CH2), 4.10–3.99 (m, 3H, H-5, H-
6a, H-6b), 2.10, 2.07, 2.04, 2.01 (4s, 12H, 4 · COCH3).
13C NMR (CDCl3, 50 MHz) d: 170.1, 169.8, 169.2,
168.8 (4 · COCH3), 133.3 (CH2ACH@CH2), 117.9
(CH2ACH@CH2), 94.7 (C-1), 70.6 (CH2ACH@CH2),
70.0, 68.6, 68.3, 67.3, 61.7 (C-6), 20.4 (2), 20.3 (2)
(4 · COCH3). HRMS: Calcd for C17H28O10N (M+NH4):
8. For the use of H2SO4–silica in carbohydrate synthesis see:
(a) Mukhopadhyay, B. Tetrahedron Lett. 2006, 47, 4337–
4341; (b) Rajput, V. K.; Mukhopadhyay, B. Tetrahedron
Lett. 2006, 47, 5939–5941; (c) Rajput, V. K.; Roy, B.;
Mukhopadhyay, B. Tetrahedron Lett. 2006, 47, 6987–
6991; (d) Dasgupta, S.; Roy, B.; Mukhopadhyay, B.
Carbohydr. Res. 2006, 341, 2708–2713; For the use of
H2SO4–silica in organic synthesis see: (e) Zolfigol, M. A.;
Bamoniri, A. Synlett 2002, 1621–1623; (f) Zolfigol, M. A.
Tetrahedron 2001, 57, 9509–9511; (g) Zolfigol, M. A.;
Shirini, F.; Ghorbani Choghamarani, A.; Mohammad-
poor-Baltork, I. Green Chem. 2002, 4, 562–564; (h) Shirini,
F.; Zolfigol, M. A.; Mohammadi, K. Bull. Korean Chem.
Soc. 2004, 25, 325–327.
9. Preparation of H2SO4–silica: To a slurry of silica gel (10 g,
200–400 mesh) in dry diethyl ether (50 mL) was added
commercially available concd H2SO4 (3 mL) with shaking
for 5 min. The solvent was evaporated under reduced
pressure resulting in free flowing H2SO4–silica which was
then dried at 110 ꢁC for 3 h.
10. Analytical data of selected compounds: Compound 1: 1H
NMR (CDCl3, 200 MHz) d: 5.50 (t, 1H, J 9.8 Hz, H-3),
5.30 (d, 1H, J 3.6 Hz, H-1), 5.10 (t, 1H, J 9.8 Hz, H-4),
4.92 (dd, 1H, J 3.6 Hz, 9.8 Hz, H-2), 4.32–4.23 (m, 3H,
CH2AC„CH, H-6a), 4.10–4.03 (m, 2H, H-5, H-6b), 2.47
(t, 1H, J 2.4 Hz, CH2AC„CH), 2.10, 2.08, 2.04, 2.02 (4s,
12H, 4 · COCH3). 13C NMR (CDCl3, 50 MHz) d: 170.5,
170.2, 169.5, 169.3 (4 · COCH3), 94.8 (C-1), 78.5
(CH2AC„CH), 75.9 (CH2AC„CH), 70.7, 70.2, 68.7,
68.1, 61.9 (C-6), 55.9 (CH2AC„CH), 20.9 (4 · COCH3).
HRMS: Calcd for C17H26O10N (M+NH4): 404.1557;
found m/z 404.1561. Compound 2: 1H NMR (CDCl3,
200 MHz) d: 5.47 (br d, 1H, J 2.2 Hz, H-4), 5.36 (dd, 1H, J
3.2 Hz, 9.8 Hz, H-3), 5.32 (d, 1H, J 3.2 Hz, H-1), 5.14 (dd,
1H, J 3.2 Hz, 9.8 Hz, H-2), 4.27 (m, 2H, CH2AC„CH),
4.14–4.07 (m, 3H, H-5, H-6a, H-6b), 2.47 (t, 1H, J 2.4 Hz,
CH2AC„CH), 2.15, 2.10, 2.05, 1.99 (4s, 12H,
4 · COCH3). 13C NMR (CDCl3, 50 MHz) d: 170.2 (2),
1
406.1713; found m/z 406.1711. Compound 11: H NMR
(CDCl3, 300 MHz) d: 5.44 (t, 1H, J 9.6 Hz, H-3), 5.04 (d,
1H, J 3.9 Hz, H-1), 5.02 (t, 1H, J 9.6 Hz, H-4), 4.82 (dd,
1H, J 3.9 Hz, 9.6 Hz, H-2), 4.25 (dd, 1H, J 4.5 Hz,
12.0 Hz, H-6a), 4.06 (dd, 1H, J 2.4 Hz, 12.0 Hz, H-6b),
3.98 (m, 1H, H-5), 3.66, 3.44 [2m, 2H, OCH2–(CH2)6–
CH3], 2.09, 2.06, 2.02, 2.00 (4s, 12H, 4 · COCH3), 1.58 [m,
2H, OCH2–CH2–(CH2)5–CH3], 1.26 [m, 10H, OCH2–
CH2–(CH2)5–CH3], 0.92 [t, 3H, OCH2–CH2–(CH2)5–
CH3]. 13C NMR (CDCl3, 50 MHz) d: 169.9, 169.7 (2),
168.7 (4 · COCH3), 95.5 (C-1), 72.8, 71.7, 68.6 (2), 67.1,
60.1 (C-6), 31.7, 29.2, 26.0 (2), 25.7, 22.5, 20.8, 20.5, 20.4
(2) (4 · COCH3), 14.0 [OCH2–CH2–(CH2)5–CH3].
HRMS: Calcd for C22H40O10N (M+NH4): 478.2652;
found m/z 478.2653. Compound 12: 1H NMR (CDCl3,
300 MHz) d: 5.45 (t, 1H, J 9.9 Hz, H-3), 5.07 (d, 1H, J
3.9 Hz, H-1), 5.04 (t, 1H, J 9.9 Hz, H-4), 4.86 (dd, 1H, J
3.9 Hz, 9.9 Hz, H-2), 4.29 (dd, 1H, J 4.2 Hz, 12.3 Hz, H-
6a), 4.11 (dd, 1H, J 2.1 Hz, 12.3 Hz, H-6b), 3.92 (m, 1H, H-
5), 3.63–3.47 [m, 2H, OCH2–(CH2)10–CH3], 2.11, 2.08,
2.04, 2.01 (4s, 12H, 4 · COCH3), 1.62 [m, 2H, OCH2–
CH2–(CH2)9–CH3], 1.29 [m, 18H, OCH2–CH2–(CH2)9–
CH3], 0.95 [t, 3H, OCH2–CH2–(CH2)9–CH3]. 13C NMR
(CDCl3, 50 MHz) d: 169.8, 169.7, 169.6, 168.9
(4 · COCH3), 95.7 (C-1), 72.6, 71.5, 68.6, 68.4, 67.0, 61.1
(C-6), 32.1, 29.7 (2), 28.5, 28.3, 27.9, 27.6, 26.5, 25.7, 22.5,
20.8 (2), 20.5, 20.4 (4 · COCH3), 14.0 [OCH2–CH2–
(CH2)9–CH3]. HRMS: Calcd for C26H48O10N (M+NH4):
169.8,
169.4
(4 · COCH3),
95.2
(C-1),
78.0
(CH2AC„CH), 75.6 (CH2AC„CH), 68.0, 67.7, 67.2,
67.1, 61.5 (C-6), 55.9 (CH2AC„CH), 21.0 (2), 20.9 (2)
(4 · COCH3). HRMS: Calcd for C17H26O10N (M+NH4):
404.1557; found m/z 404.1559. Compound 3: 1H NMR
(CDCl3, 300 MHz) d: 5.30 (dd, 1H, J 2.4 Hz, 9.3 Hz, H-3),
5.26 (m, 2H, H-2, H-4), 5.02 (s, 1H, H-1), 4.29 (br d, 2H, J
2.1 Hz, CH2AC„CH), 4.28 (dd, 1H, J 4.2 Hz, 12.3 Hz,
H-6a), 4.10 (dd, 1H, J 2.4 Hz, 12.3 Hz, H-6b), 4.08 (m, 1H,
H-5), 2.47 (t, 1H, J 2.1 Hz, CH2AC„CH), 2.20, 2.11,
2.05, 2.00 (4s, 12H, 4 · COCH3). 13C NMR (CDCl3,
50 MHz) d: 170.4, 169.7, 169.6 (2) (4 · COCH3), 96.5
(C-1), 78.3 (CH2AC„CH), 76.1 (CH2AC„CH), 69.6,
69.4, 69.2, 66.3, 62.5 (C-6), 55.6 (CH2AC„CH), 21.1 (2),
20.9 (2) (4 · COCH3). HRMS: Calcd for C17H26O10N
(M+NH4): 404.1557; found m/z 404.1560. Compound 4:
1H NMR (CDCl3, 300 MHz) d: 5.76 (d, 1H, J 9.3 Hz,
NH), 5.18 (t, 1H, J 9.6 Hz, H-3), 5.11 (t, 1H, J 9.6 Hz,
H-4), 5.01 (d, 1H, J 3.9 Hz, H-1), 4.32 (dt, 1H, J 3.9 Hz,
9.3 Hz, 9.6 Hz, H-2), 4.27 (m, 2H, CH2AC„CH), 4.23
(dd, 1H, J 4.5 Hz, 12.3 Hz, H-6a), 4.07 (dd, 1H, J 2.4 Hz,
12.3 Hz, H-6b), 3.96 (m, 1H, H-5), 2.47 (t, 1H, J 2.4 Hz,
CH2AC„CH), 2.09, 2.02, 2.01 (3s, 9H, 3 · COCH3), 1.95
(s, 3H, NHCOCH3). 13C NMR (CDCl3, 50 MHz) d: 171.3,
1
534.3278; found m/z 534.3280. Compound 13: H NMR
(CDCl3, 300 MHz) d: 5.45 (t, 1H, J 9.3 Hz, H-3), 5.13 (d,