Regioselective pyrrole synthesis from asymmetric β-diketone and conversion to sterically hindered porphyrin

Article abstract of DOI:10.1016/S0040-4039(97)00039-7

The condensation of asymmetric β-diketones with α-oximinoacetoacetate esters affords pyrroles regioselectively. The mechanism of the regioselectivity is studied using ¹³C-NMR spectroscopy. Pyrrole having a neopentyl group at the 4-position is synthesized by the method, and further converted to a steric hindered porphyrin in good yield.