Design, synthesis, and interaction study of quinazoline-2(1 H)-thione derivatives as novel potential Bcl-xL inhibitors

DOI: 10.1021/jm901004c

Source and publish data:

Journal of Medicinal Chemistry p. 3465 - 3479 (2010)

Update date:2022-08-05

Topics:

Authors:

Feng, Yu

Ding, Xiao

Chen, Tao

Chen, Lili

Liu, Fang

Jia, Xu Jia, Xu

Luo, Xiaomin

Shen, Xu

Chen, Kaixian

Jiang, Hualiang

Wang, Hui

Liu, Hong

Liu, Dongxiang

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Article abstract of DOI:10.1021/jm901004c

Development of inhibitors to antagonize the activities of antiapoptotic Bcl-2 family proteins is of particular interest in cancer chemotherapy. We discovered a quinazoline-2(1H)-thione derivative (DCBL55) as a new Bcl-x _L, Bcl-2, and Mcl-1 inhi

Full text of DOI:10.1021/jm901004c

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