Halichondrin B: Synthesis of a C1-C14 model via desymmetrization of (+)-conduritol E

DOI: 10.1021/ol027389a

Source and publish data:

Organic Letters p. 515 - 518 (2003)

Update date:2022-08-02

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Authors:

Lambert, William T.

Burke, Steven D.

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Article abstract of DOI:10.1021/ol027389a

(Matrix presented) A model C1-C14 segment (1) of halichondrin B was synthesized from (+)-conduritol E (7) in 18 steps and 2.9% overall yield. Key features of the synthesis include the novel ozonolytic desymmetrization of C₂-symmetric diol 6, th

Full text of DOI:10.1021/ol027389a

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