An improved synthesis of 5,7-dimethoxy-4-methyl-phthalide, a key intermediate in the synthesis of mycophenolic acid

Article abstract of DOI:10.1080/00397919608003548

An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phth

Full text of DOI:10.1080/00397919608003548

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Improved Synthesis of 5,7-
Dimethoxy-4-methylphthalide,
A Key Intermediate in the
Synthesis of Mycophenolic Acid
Gergely M. Makara a , Kevin Klubek a & Wayne K.
Anderson a
a Department of Medicinal Chemistry , School of
Pharmacy, State University of New York at Buffalo ,
Buffalo, NY, 14260
Published online: 21 Aug 2006.
To cite this article: Gergely M. Makara , Kevin Klubek & Wayne K. Anderson (1996) An
Improved Synthesis of 5,7-Dimethoxy-4-methylphthalide, A Key Intermediate in the
Synthesis of Mycophenolic Acid, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 26:10, 1935-1942, DOI:
10.1080/00397919608003548
To link to this article: http://dx.doi.org/10.1080/00397919608003548
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