Bioorganic and Medicinal Chemistry Letters p. 1943 - 1947 (2005)
Update date:2022-08-03
Topics:
Hamdouchi, Chafiq
Zhong, Boyu
Mendoza, Jose
Collins, Elizabeth
Jaramillo, Carlos
De Diego, Jose Eugenio
Robertson, Daniel
Spencer, Charles D.
Anderson, Bryan D.
Watkins, Scott A.
Zhang, Faming
Brooks, Harold B.
Structure-based design approach was successfully used to guide the evolution of imidazopyridine scaffold yielding new structural class of highly selective inhibitors of cyclin dependent kinases that were able to form a new interaction with an identified residue of the protein, Lys89. Compounds from this series have shown no detectable effect when tested against a representative set of other serine/threonine kinases such as GSK3β, CAMKII, PKA, PKC-α,β,ε,γ. Compound 2i inhibits proliferation in HCT 116 cells in tissue culture. Synthesis, co-crystal structure of CDK2 in complex with compound 2i, and preliminary SAR study are disclosed.
View MoreFeis International Trade Co,. Ltd
Contact:13961823444-18235944442
Address:Wuxi jiangsu
Contact:+86-18653358619
Address:zibo
Qingdao Kylin Trading Co., Ltd.
Contact:0086-532-68979884/58972912/68972263/65/88171519
Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
jiangsu haian chemical co.,ltd.
Contact:86-513-15851283853
Address:No.99,Changjiang West Road,Haian County,Jiangsu Province,China
Suzhou Jingye Medicine & Chemical Co., Ltd
website:http://www.jingyechem.cn
Contact:+86-512-66658588
Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Doi:10.1002/chem.200601488
(2007)Doi:10.1002/jhet.3740
(2019)Doi:10.1021/ja00803a041
(1973)Doi:10.1055/s-2006-950206
(2006)Doi:10.1002/oms.1210100605
(1975)Doi:10.1002/1099-0690(200211)2002:21<3595::AID-EJOC3595>3.0.CO;2-F
(2002)