A bisubstrate reagent orchestrating adenosine triphosphate and L-tyrosine and making tyrosyl adenylate: Partial mimicking of tyrosyl-tRNA synthetase

Article abstract of DOI:10.1039/c8ob02866d

We report the development of a bisubstrate reagent that, similar to tyrosyl t-RNA synthetase (TyrTS), provides a surface for ATP and l-Tyr to render a pseudo-intramolecular reaction forming 5′-tyrosyl adenylate (tyrAd). The presence of the reagent in solu