Conjugate addition reactions of α-aminoalkylcuprates with α,β-enones and enals

Article abstract of DOI:10.1016/S0040-4020(00)00130-7

Deprotonation of Boc-protected amines with sec-BuLi or transmetallation of α-aminostannanes with n-BuLi affords α-aminoalkyllithium reagents which can be converted into α-aminoalkylcuprate reagents with CuCN or THF soluble CuCN·2LiCl. These reagents under