Chemical and Pharmaceutical Bulletin p. 399 - 404 (2000)
Update date:2022-08-04
Topics:
Hanaoka, Miyoji
Hirasawa, Taeko
Cho, Won Jea
Yasuda, Shingo
New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with α- chloro-α-(methylthio)acetyl chloride, followed by cyclization with stannic chloride, furnished the key intermediates 4-methylthio-3- phenethylisoquinolin-3-ones (14), which were methylated to provide their methyl derivatives (17). Both isoquinolin-3-ones (14, 17) were easily transformed into protoberberine alkaloids (16) and their 13-methyl alkaloids (21) in good yield.
View MoreValiant Fine Chemicals Co., Ltd.
Contact:+86 535 6101878/6374484
Address:11 Wuzhishan Rd.,YTETDZ,Yantai,264006,Shandong,China
Shanghai Bojing Chemical Co., Ltd.
Contact:021-37122233
Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
website:http://www.acrospharmatech.com
Contact:+1-3234804688
Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong
Chongqing Changfeng Chemical Co., Ltd.
website:http://www.changfengchem.com
Contact:+86-23-67896333
Address:30th Floor, Longhu Ziduxingzuo Building A, 1st Branch,YuSong Rd., Yubei District, Chongqing, China
Contact:0571-
Address:zhejing
Doi:10.1246/bcsj.57.605
(1984)Doi:10.1016/S0040-4020(02)01400-X
(2002)Doi:10.1016/S0040-4039(01)87115-X
(1973)Doi:10.1016/j.jfluchem.2003.09.006
(2004)Doi:10.1021/ja01165a068
(1950)Doi:10.1021/jm00244a008
(1975)
