PREPARATION OF DIASTEREOISOMERIC 2-DEUTERIO-3-HYDROXY BUTYRATE. A GENERAL METHOD FOR HYDROGENATION OF β-ACYLOXY-α,β-UNSATURATED CROTONATES

Article abstract of DOI:10.1016/S0040-4039(00)86736-2

Both erythro- and threo-2-deuterio-3-hydroxybutyrate are prepared selectively, with a hydrogenation over 5percent rhodium on carbon catalyst serving as a key step.This hydrogenation is general for β-acyloxy-α,β-unsaturated crotonates.