Enaminonitriles in heterocyclic synthesis: A route to 1,3-diaryl-4- Aminopyrazole derivatives

Article abstract of DOI:10.3390/molecules18010535

Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-Aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-Arylhydrazno-2-Arylethane nit

Full text of DOI:10.3390/molecules18010535

Molecules 2013, 18, 535-544; doi:10.3390/molecules18010535
OPEN ACCESS
molecules
ISSN 1420-3049
www.mdpi.com/journal/molecules
Article
Enaminonitriles in Heterocyclic Synthesis:
A Route to 1,3-Diaryl-4-aminopyrazole Derivatives
Hanadi Y. Medrasi 1, Mariam Abdullah Al-Sheikh 1,* and Abdellatif Mohamed Salaheldin 2
1
Department of Chemistry, Sciences faculty for Girls, King AbdulAziz University, Jeddah,
P.O. Box 13343, Jeddah 21493, Saudi Arabia
2
Department of Chemistry, College of Applied Sciences, Umm Al-Qura University, P.O. Box 13401,
Makkah 21955, Saudi Arabia
* Author to whom correspondence should be addressed; E-Mail: r1425@hotmail.com;
Tel.: +966-050-569-4706.
Received: 29 October 2012; in revised form: 15 November 2012 / Accepted: 24 December 2012 /
Published: 2 January 2013
Abstract: Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate
and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles.
These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane
nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using
the Thorpe-Ziegler cyclization.
Keywords:
enaminonitriles;
4-aminopyrazole;
Thorpe-Ziegler
cyclization;
microwave irradiation
1. Introduction
The synthesis and chemistry of 4-aminopyrazole-5-carboxylic acid derivatives is now receiving
considerable interest [1–4]. Potential applications in pharmaceutical industry are most likely behind this
interest. For example, ethyl 3-butyl-4-aminopyrazole-5-carboxylate is a key intermediate in synthesis of
Viagra (Figure 1) [5,6] while 5-aminopyrazole-4-carboxamide is the building block for the synthesis of
allopurinol (Figure 1). 4-Aminopyrazoles has been generally prepared via nitration of pyrazoles and
subsequent reduction of the formed 4-nitropyrazole but such approach requires discarding large amounts
of hazardous acid waste [1,2], which could be minimized as recently reported [7]. The ring
transformation reaction of 1,2,4,5-tetrazines to 4-aminopyrazoles by cyanotrimethylsilane (TMSCN) [8];

Molecules 2013, 18
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addition of nitrile imines to benzo-1,4-oxazines [9] or reaction of ethyl diazoacetate with benzyl cyanide
are alternate routes to 4-aminopyrazoles [10], but again these either utilize explosive starting materiales
or rather expensive ones. A route to 4-aminopyrazoles via a Gabriel-like synthesis has also been recently
reported, but this approach is not atom economic and also employs expensive dimethylformamide
dimethylacetal (cf. Scheme 1) [11].
Figure 1. Structure of Viagra and Allopurinol.
O
Me
N
OEtHN
N
HN
N
O
N
nPr
N
O2S
N
N
H
N
Allopurinol
Me
sildenafil (Viagra)
Scheme 1. Literatures preparation of 4-aminopyrazole derivatives.
O
R1
NH2
R1
NMe2
Ph
NH2NH2
N
i) HNO3/ H2SO4
ii) SnCl2/HCl
N
N
R2
R2
N
R
N
R
O
O
DMFDMA
O
N
Ph
N
N
N
N
TMSCN
CO2Me
MeO2C
Ar
N
N
Ph
Ar = 4-MeC6H4
CO2Et
O
O
O
R = H, Ph
R1 = CO2Me, Ph, 4-MeC6H4
R2 = Me, CO2Me
N
COPh
Microwave-assisted reactions have received great interest in synthetic organic chemistry. Microwave
heating has been employed as a frequent resource for improvement of classical reactions. The major
benefits of performing reactions under microwave condition are: shorter reaction times, ease of isolation
of the products after easy work-up, significant rate enhancements and higher product yields as compared
to reactions run under conventional heating [12–14].

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537
2. Results and Discussion
In conjunction to our interest in chemistry of pyrazoles [15–17] and condensed pyrazoles [18–20] we
decided to develop an efficient route to the title compounds. A logical route to these compounds would
be the reaction of hydrazones 1a,f with functionally substituted alkyl halides to yield targeted
compounds 3 via intermediate 2. Although 1a–c can be readily obtained from reaction of 4 with cyanide
ion following a procedure similar to that described earlier [21], this approach was discarded based on the
apparent hazards. We firstly considered the reaction of aldehyde hydrazones 5 as a route to 6 that can
then be converted to 1 via reaction with hydroxylamine in a microwave oven as has been recently
reported from our laboratories. However, under such conditions cinnolines 7 [18] were the only products
obtained (cf. Scheme 2).
Scheme 2. Preparation of 4-aminopyrazoles.
R1
CN
R1
NH2
Y
Y
R1
CN
X
N
N
N
TEA
X = Cl or Br
N
Y
N
NH
R2
R2
2
R2
3a-e
1a
, R1 = 4-NO2C6H4; R2 = C6H5
f, R1 = C6H5; R2 = 4-NO2C6H4
3a
, R1 = 4-NO2C6H4; R2 = C6H5: Y = CN
b, R1 = C6H5; R2 = 4-NO2C6H4; Y = CN
c, R1 = C6H5; R2 = 4-NO2C6H4; Y = CO2Et
, R1 = C6H5; R2 = 4-NO2C6H4; Y = COCH3
e, R1 = C6H5; R2 = 4-NO2C6H4; Y = COPh
CN
Cl
R1
d
N
NHR2
4
R1
R1
CHO
NH
R1
POCl3
DMF
NH2OH.HCl
N
N
NH
R2
N
AcOH/AcONa
MW
N
R2
6
7
5
The methylene group in p-nitrobenzylcyanide (8a) was sufficiently acidic to couple directly with
benzenediazonium chlorides to yield 1a–c and thus initial conversion into enamine was not needed.
Condensation of 8a with dimethylformamide dimethylaceteal (DMFDMA) under reflux for 3 h.
produced 9a in 70% yield.
Trials to condense benzyl cyanide (8b) with DMFDMA to obtain 9b failed, as the volatility of the
reagent did not allow for the use of high reaction temperatures. Consequently we decided to generate less
volatile formamide acetals in situ thus allowing for employing higher temperatures. We could thus
successfully prepare 11a,b via refluxing triethyl orthoformate, piperidine or morpholine with benzyl
cyanide in dimethylformamide solution under reflux for 72 h. (cf. Scheme 3) [22]. Although it is
possible that the initially formed ethoxyacrylonitrile (11c) reacted with the secondary amine, this
possibility could be readily excluded as benzyl cyanide failed to condense with triethyl orthoformate
under reflux with DMF in the absence of secondary amine. We thus believe that the acetals 10a,b are

Molecules 2013, 18
538
initially formed and then these react with benzyl cyanide to yield 11a,b. This condensation could be
effected by microwave heating for 20 min to obtain 11a,b, and were found identical in all details
(melting point and TLC analysis, NMR) to the compounds obtained under conventional heating.
We have decided to test the possibility that enaminonitriles 11 can couple with aromatic diazonium
salts to yield intermediates 12 that would be readily converted into 13 and consequently into 1d–f [23]
via a Japp-Klingmann cleavage [24], a similar coupling process that has been previously reported by us [15].
Scheme 3. Preparation of hydrazones 1a–f.
O2N
R1
CN
CN
R1
CN
DMFDMA
N
R2N=N Cl
NH
R2
8a
8a, R1 = 4-NO2C6H4
8b, R1 = C6H5
8a
NMe2
9a
1a-f
1a, R1 = 4-NO2C6H4; R2 = C6H5
b
, R1 = 4-NO2C6H4; R2 = 4- ClC6H4
c, R1 = R2 = 4-NO2C6H4
, R1 = R2 = C6H5
H
N
d
EtO
EtO
OEt
e, R1 = C6H5; R2 = 4-ClC6H4
f, R1 = C6H5; R2 = 4-NO2C6H4
DMF
+
N
X
EtO
OEt
X
10
8b
R2
R2
Ph
CN
N
R2N=N Cl
N
N
N
H2O
Ph
CN
Cl
R
N
Ph
CN
11a, R =
N
H
O
11 b
, R =
N
O
X
13
11c, R = OEt
12
Enaminonitriles 1 were found to be good candidates to obtain 4-aminopyrazoles based on a
Thorpe-Ziegler cyclization [25,26]. In this method, N-alkylation of enaminonitrile was carried out using
α-haloketones in anhydrous DMF in the presence of K2CO3 as the base. Moreover, compounds having
an aryl substituent on the amino moiety of the enamine group were the most convenient for alkylation
and spontaneous intramolecular cyclization. The presence of this group facilitates the formation of the
N-anion required for alkylation and subsequent carbanion formation for the cyclization involving
the cyano group. The reaction of enaminonitrile 1 with chloroacetonitrile, chloroacetone, ethyl
bromoacetate and α-bromoacetophenone in DMF/K2CO3 afforded the corresponding 4-aminopyrazole
derivatives 3a–e in low yield (27–44%) via intermediate 2. We prepared compound 3 by a modification
of the method used by Gewald et al. [24,25] using triethylamine as base. When the reaction was carried
out in an excess of triethylamine solution, the desired 4-aminopyrazole derivatives 3a–e are obtained in
a satisfactory yield (77–92%).

Molecules 2013, 18
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The structure of compounds 3a–e was established on the basis of elemental analysis, IR, mass, 1H and
1
13C-NMR spectral data studies (cf. Experimental Section). For example, the H-NMR spectrum of
compound 3a showed the absence of a signal for a methylene function and the presence of a two proton
D2O-exchangeable signal at δ = 6.45 ppm for the amino function and the aromatic protons in the proper
13
positions. C-NMR and mass spectra of compound 3a are in agreement with the proposed structure.
This synthesis thus opens a new route for synthesis of 4-aminopyrazole-5-carbonitriles; important
intermediates in synthesis of pharmaceuticals (e.g., Viagra). The scope of this synthetic approach is
being now explored.
3. Experimental
3.1. General
All melting points are uncorrected. IR spectra were recorded in KBr with a Bruker Vector 22
13
(Ettlingen, Germany) spectrophotometer. The 1H-NMR (300 MHz) and C-NMR (75.4 MHz) spectra
were recorded on a Varian Mercury 300 MHz spectrometer in DMSO-d6 as solvent and TMS as internal
standard; chemical shifts are reported in δ units (ppm). Mass spectra were measured at 70 eV using a
Shimadzu GCMS-QP-1000 EX mass spectrometer. Microanalyses were performed on a LECO
CHN-932 by the Microanalysis Unit of Cairo University. Microwave experiments were conducted in a
CEM MARS oven.
3.2. Preparation of Substituted Aryl Hydrazonoacetonitriles 1a–f
A cold solution of aryldiazonium salt (10 mmol) was prepared by adding a solution of sodium nitrite
(10 mmol in H2O) to a cold solution of the aromatic amine hydrochloride with stirring. The resulting
solution of the aryldiazonium salt was added to a cold solution of p-nitrobenzylcyanide (8a, 1.62 g,
10 mmol), 2-phenyl-3-piperidin-1-yl-acrylonitrile (11a) or 3-morpholin-4-yl-2-phenyl-acrylonitrile
(11b) in ethanol (50 mL) containing sodium acetate (5 g). The reaction mixture was stirred at room
temperature for 30 min. The solid product, so formed, was collected by filtration, washed with water and
crystallized from the appropriate solvent.
4-Nitrophenyl(phenylhydrazono)acetonitrile (1a). Yield 70%. m.p. 200–201 °C (lit. m.p. = 198 °C [23]).
IR:  = 3380 (NH), 2208 (CN), 1463, 1376 (NO2) cm−1. 1H-NMR:  = 6.99–7.25 (m, 5-H, Ar-H), 7.30 (s,
1H, NH), 7.75 (d, 2H, J = 10 Hz, Ar-H), 8.22 (d, 2H, J = 10 Hz, Ar-H). 13C-NMR:  = 157.2 (C=N),
155.2, 144.1, 137.4, 130.2, 129.1, 124.5, 123.4, 120.2, 117.2 (CN). MS (EI): m/z (%) = 266 (M+, 89%).
Anal. Calcd. for C14H10N4O2 (266.25): C, 63.15; H, 3.79; N, 21.04. Found: 63.05; H, 3.80; N, 21.10.
(4-Chlorophenyl)hydrazono(4-nitrophenyl)acetonitrile (1b). Yield 79%. m.p. 225–227 °C. IR:  = 3395
1
(NH), 2218 (CN), 1460, 1372 (NO2) cm−1. H-NMR:  = 6.80 (d, 2H, J = 9.5 Hz, Ar-H), 7.20 (d, 2H,
J = 9.5 Hz, Ar-H), 7.35 (s, 1H, NH), 7.56 (d, 2H, J = 10 Hz, Ar-H), 8.29 (d, 2H, J = 10 Hz, Ar-H).
MS (EI): m/z (%) = 300 (M+, 65%). Anal. Calcd. for C14H9ClN4O2 (300.70) C, 55.92; H, 3.02; Cl, 11.79;
N, 18.63. Found: 55.80; H, 3.00; Cl, 11.90; N, 18.55.

Molecules 2013, 18
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(4-Nitrophenyl)-(4-nitrophenyl)hydrazonoacetonitrile (1c). Yield 75%. m.p. 235–236 °C. IR:  = 3385
(NH), 2220 (CN); 1466, 1379 (NO2) cm−1. 1H-NMR:  = 6.90 (d, 2H, J = 10 Hz, Ar-H), 7.10 (s, 1H, NH),
7.65 (d, 2H, J = 10 Hz, Ar-H), 7.86 (d, 2H, J = 10 Hz, Ar-H), 8.15 (d, 2H, J = 10 Hz, Ar-H). MS (EI): m/z
(%) = 311 (M+, 87%). Anal. Calcd. for; C14H9N5O4 (311.25): C, 54.02; H, 2.91; N, 22.50. Found: C,
53.90; H, 2.80; N, 22.45.
Phenyl(phenylhydrazono)acetonitrile (1d). Yield 68%, m.p. 100–102 °C. IR:  = 3360 (NH), 2210 (CN)
cm−1. 1H-NMR:  = 6.99–7.25 (m, 5-H, Ar-H), 7.30 (s, 1H, NH), 7.40–7.62 (m, 5-H, Ar-H). MS (EI):
m/z (%) = 221 (M+, 89%). Anal. Calcd. for C14H11N3 (221.26): C, 76.00; H, 5.01; N, 18.99. Found:
75.90; H, 5.10; N, 19.05.
(4-Chlorophenyl)hydrazonophenyl acetonitrile (1e). Yield 82%, m.p. 180–182 °C (lit. m.p. = 168 °C [23]).
IR:  = 3360 (NH), 2215 (CN) cm−1. 1H-NMR:  = 7.00 (d, 2H, J = 10 Hz, Ar-H), 7.18 (d, 2H, J = 10 Hz,
Ar-H), 7.28 (s, 1H, NH), 7.35–7.65 (m, 5-H, Ar-H). MS (EI): m/z (%) = 255 (M+, 81%). Anal. Calcd. for
C14H10ClN3 (255.70): C, 65.76; H, 3.94; Cl, 13.86; N, 16.43. Found: C, 65.70; H, 3.80; Cl, 13.90; N, 16.55.
(4-Nitrophenyl)hydrazonophenylacetonitrile (1f). Yield 77%, m.p. 212–214 °C (lit. m.p. = 214 °C [23]).
IR:  = 3385 (NH), 2220 (CN) 1460, 1372 (NO2) cm−1; 1H-NMR:  = 6.95 (d, 2H, J = 10 Hz, Ar-H), 7.07
(s, 1H, NH), 7.25–7.68 (m, 5H, Ar-H), 7.92 (d, 2H, J = 10 Hz, Ar-H). MS (EI): m/z (%) = 266 (M+,
91%). Anal. Calcd. for C14H10N4O2 (266.25): C, 63.15; H, 3.79; N, 21.04. Found: C, 63.20; H, 3.85;
N, 21.15.
3.3. General Procedure for Preparation of 4-Aminopyrazole Derivatives 3a–e
Method A. A mixture of 1a,f (0.01 mol), the α-halo compound (chloroacetonitrile, chloroacetone,
ethyl bromoacetate and α-bromoacetophenone, 0.011 mol), and potassium carbonate (2.0 g) in
dimethylformamide (20 mL) was stirred for 1 h, at 90 °C, in an oil-bath. The reaction mixture was
cooled and poured into water (60 mL). The precipitated solid products formed were filtered off, washed
thoroughly with cold water and recrystallized from EtOH to afford the corresponding cyclized products
3a (40 %), 3b (47%), 3c (39%), 3d (35%), 3e (22%).
Method B. To a solution of the intermediate 1a,f (0.01 mol) the α-halo compound (chloroacetonitrile,
chloroacetone, ethyl bromoacetate and α-bromoacetophenone, 0.011 mol) and triethylamine (4 mL)
were added with external cooling. The reaction mixture was refluxed for 20–30 min, after cooling
(50 mL) water was added, the solid product was filtered off, washed thoroughly with cold water and
crystallized from ethanol (in the case of 3a, 88%, 3b, 92). For derivatives 3c–e a brown oil was
separated, the water was decanted and the oil was extracted with CH2Cl2 (3 × 25 mL) and the combined
organic layers were dried (Na2SO4), filtered and the solvent was evaporated to give a solid which was
crystallized from EtOH.
4-Amino-3-(4-nitrophenyl)-1-phenyl-1H-pyrazole-5-carbonitrile (3a). Yield 88%, m.p. 187–188 °C;
1
IR:  = 3310–3250 (NH2), 2224 (CN), 1463, 1375 (NO2) cm−1; H-NMR:  = 6.45 (s, 2H, NH2),
13
7.25–7.38 (m, 5H, Ar-H), 7.62 (d, 2H, J = 10 Hz, Ar-H), 8.10 (d, 2H, J = 10 Hz, Ar-H); C-NMR:
 = 98.98 (C-5), 113.23 (CN), 116.13 (C-2′, 6′), 123.38 (C-3′′, 5′′), 123.71 (C-4′), 129.38 (C-2′′, 6′′), 129.82

Molecules 2013, 18
541
(C-3′, 5′), 140.05 (C-1′), 144.77 (C-1′′), 145.23 (C-3), 146.90 (C-4), 147.65 (C-4′′). MS (EI): m/z (%) = 305
(M+, 100%). Anal. Calcd. for C16H11N5O2 (305.): C, 62.95; H, 3.63; N, 22.94. Found: C, 63.10; H, 3.85;
N, 23.05.
4-Amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazole-5-carbonitrile (3b). Yield 92%, m.p. 178–180 °C IR:
 = 3320–3240 (NH2), 2228 (CN) 1466, 1369 (NO2) cm−1, 1H-NMR:  = 6.49 (s, 2H, NH2), 7.25–7.48
(m, 5H, Ar-H), 7.55 (d, 2H, J = 10 Hz, Ar-H), 8.20 (d, 2H, J = 10 Hz, Ar-H). MS (EI): m/z (%) = 305
(M+, 85%). Anal. Calcd. for C16H11N5O2 (305): C, 62.95; H, 3.63; N, 22.94. Found: C, 63.10; H, 3.85;
N, 23.05. Found: C, 63.00; H, 3.65; N, 22.80.
Ethyl 4-amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazole-5-carboxylate (3c). Yield (74%), m.p. 165–166 °C;
IR: ν = 3492–3380 (NH2), 1715 (C=O) cm−1. 1H-NMR: δ = 0.98 (t, 3H, J = 7.5Hz, CH3), 4.04 (q, 2H,
J = 7.5 Hz, CH2), 5.94 (s, 2H, NH2), 7.21 (d, 2H, J = 9 Hz, Ar-H), 7.28 (t, 1H, J = 8 Hz, Ar-H), 7.31–7.39
13
(m, 4H, Ar-H), 8.14 (d, 2H, J = 9 Hz, Ar-H). C-NMR: δ = 14.12 (CH3), 59.10 (CH2), 108.72 (C-5),
113.53 (C-3′,5′), 121.23 (C-2′′,6′′), 127.21 (C-2′,6′), 127.94 (C-4′′), 132.14 (C-1′), 132.92 (C-3′′,5′′),
137.31 (C-1′′), 141.96 (C-3), 146.41 (C-4), 150.86 (C-4′), 160.32 (C=O). MS (EI): m/z (%) = 352 (M+, 77%).
Anal. Calcd. For C18H16N4O4 (352.12): C, 61.36; H, 4.58; N, 15.90. Found C, 61.55; H, 4.42; N, 16.12.
1-(4-Amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazol-5-yl)ethanone (3d). Yield: 77%, m.p. 192–193 °C.
IR: ν = 3440–3348 (NH2), 1678 (C=O) cm−1. 1H-NMR: δ = 2.23 (s, 3H, CH3), 6.67 (s, 2H, NH2), 7.09 (t,
1H, J = 9 Hz, Ar-H), 7.36 (d, 2H, J = 9 Hz, Ar-H), 7.42–7.55 (m, 4H, Ar-H), 8.23 (d, 2H, J = 9 Hz,
Ar-H). 13C-NMR:  = 28.52 (CH3), 114.28 (C-3′,5′), 118.20 (C-5), 122.12 (C-2′′,6′′), 127.93 (C-2′,6′),
128.51 (C-4′′), 132.21 (C-1′), 133.62 (C-3′′,5′′), 138.64 (C-1′′), 143.31 (C-3), 147.45 (C-4), 149.38
(C-4′), 186.21 (C=O). MS (EI): m/z (%) = 332 (80) [M]+. Anal. Calcd. For C17H14N4O3 (322.32): C,
63.35; H, 4.38; N, 17.38. Found C, 63.49; H, 4.17; N, 17.15.
(4-Amino-1-(4-nitrophenyl)-3-phenyl-1H-pyrazol-5-yl)(phenyl)methanone (3e). Yield: 72%; m.p.
224–226 °C. IR: ν = 3452–3367 (NH2), 1690 (C=O) 1465, 1372 (NO2) cm−1. 1H-NMR: δ = 6.58 (s, 2H,
NH2), 7.14 (d, 2H, J = 9 Hz, Ar-H), 7.20–7.26 (m, 4H, Ar-H), 7.30–7.38 (m, 6H, Ar-H), 8.12 (d, 2H,
J = 9 Hz, Ar-H). MS (EI): m/z (%) = 384 (42) [M]+. Anal. Calcd. For C22H16N4O3 (384.39): C, 68.74; H,
4.20; N, 14.58. Found C, 68.60; H, 4.44; N, 14.70.
3.4. 3-Dimethylamino-2-(4-nitrophenyl) acrylonitrile (9a)
A mixture of 8a (0.01 mol) and DMFDMA (0.012 mol) in dioxane (15 mL) was refluxed for three
hours then cooled and poured onto water. The green solid product, so formed, was collected by filtration
and crystallized from ethanol to give 9a. Yield 70%; m.p. 178–180 °C. IR:  = 2222 (CN), 1610 (C=C)
1
cm−1. H-NMR:  = 3.27 (s, 3H, CH3), 3.33 (s, 3H, CH3), 7.50 (d, 2H, J = 9Hz, Ar-H), 7.80 (s, 1H,
13
olefinic-H), 8.12 (d, 2H, J = 9Hz, Ar-H). C-NMR:  = 43.64 (2CH3), 97.27 (C=CH), 122.54 (CN),
123.36, 132.40, 144.45, 145.75, 150.50 (C=CH). MS (EI): m/z (%) = 217 (100) [M+]. Anal. Calcd. For
C11H11N3O2 (217.22): C, 60.82, H, 5.10, N, 19.34. Found C, 60.85, H, 5.03, N, 19.30.

Molecules 2013, 18
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3.5. 3-Substituted Amino-2-phenylacrylonitriles 11a,b
Method A. To a mixture of benzyl cyanide 8b (0.3 mol), triethyl orthoformate (0.32 mol), and
piperidine or morpholine (0.3 mol each) DMF (40 ml) was added and the solution was refluxed for 72 h.
The reaction mixture was then cooled and poured onto water. The solid product formed, was collected
by filtration and crystallized from ethanol, (11a 70%; 11b 65%).
Method B. Under Microwave irradiation. In a round bottom flask of 100 mL equipped with a
condenser, benzyl cyanide 8b (0.3 mol), triethyl orthoformate (0.32 mol), and piperidine or morpholine
(0.3 mol each) DMF (40 ml) was added and the mixture was heated at reflux during 20 min under
microwave irradiation (at a constant power of 400 W). After cooling to r.t., the reaction mixture was
poured onto water to give a solid, which was identical in all respects with that obtained from the above
reactions (TLC, m.p., NMR), (11a 85%; 11b 77%).
2-Phenyl-3-piperidin-1-yl-acrylonitrile (11a). Yield: 85%, m. p. 116–117 °C. IR:  = 2190 (CN), 1616
(C=C) cm−1. 1H-NMR:  = 1.60 (s, 6H, 3CH2), 3.63 (s, 4H, 2CH2), 7.16 (s, 1H, olefinic-H), 7.26–7.45
(m, 5 H, Ar-H). 13C-NMR:  = 24.36, 26.41, 51.96, 75.41 (C=CH), 121.59 (CN), 124.48, 125.51,
129.14, 137.27, 149.29 (C=CH). MS (EI): m/z (%) = 212 (42) [M+]. Anal. Calcd. For C14H16N2 (212.29):
C, 79.21, H, 7.60, N, 13.20. Found C, 79.29, H, 7.67, N, 13.17.
3-Morpholin-4-yl-2-phenyl-acrylonitrile (11b). Yield 77%, m.p. 105–106 °C; IR:  = 2205 (CN), 1620
(C=C). 1H-NMR:  = 2.85 (t, 4H, 2CH2), 3.75 (t, 4H, 2CH2), 6.92 (s, 1H, olefinic-H), 7.15–7.39 (m, 5H,
Ar-H). MS (EI): m/z 214 (M+, 93%). Anal. Calcd. For C13H14N2O2 (214.): C, 72.87; H, 6.59; N, 13.07.
Found: C, 72.80; H, 6.55; N, 13.10.
4. Conclusions
Enaminonitriles could be easily obtained by reaction of benzyl cyanide or 4-nitrobenzyl cyanide with
DMFDMA or with triethylorthoformate and piperidine or morpholine in the presence of DMF, in situ
generation of less volatile amide acetals from piperidine diethylacetal would enable avoiding the
application of drastic reaction conditions in the condensation of amide acetals with active methylenes,
thus further application of condensation reaction to less reactive methylenes can be applied. This method
involves the of less expensive chemicals and conversion of methylenes to enamines enhances reactivity
toward electrophiles. Shorter reaction times and higher yields were obtained by microwave irradiation.
Acknowledgements
We are grateful to E.A. Hafez for continued help and critical comments on our research progress.
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Sample Availability: Samples of the compounds 1a–f, 9a and 11a,b are available from the authors.
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